Searchable abstracts of presentations at key conferences in endocrinology

ea0063oc9.3 | Thyroid 2 | ECE2019

Novel driver mutations in thyroid cancer recurrence

Nieto Hannah , Thornton Caitlin , Fletcher Alice , de Menezes Albert Nobre , Baker Kate , Alshahrani Mohammed , Read Martin , Boelaert Kristien , Smith Vicki , Baptiste Cazier Jean , Mehanna Hisham , McCabe Chris

The incidence of thyroid cancer is rapidly increasing worldwide. Whilst outcome in thyroid cancer is generally good, up to 25% of patients develop recurrence, and have a significantly reduced life expectancy. We hypothesise those thyroid tumours which subsequently recur display a distinct pattern of driver events. Whole exome sequencing data were downloaded from The Cancer Genome Atlas (TCGA). Bioinformatic analysis of data on N=43 patients whose tumours recurred was ...